The 3M P100 combination cartridge for organic vapors is designed to provide optimal respiratory protection in demanding industrial environments. Compatible with 3M respirators from the 6000, 7000 and FF-400 series, it combines particle filtration and gas absorption for enhanced safety. Ideal for professionals exposed to solvents, chemical vapors, and hazardous airborne particles.
No returnable if used. For more information about our return policy, please refer to the Orders and Returns.
Manufacturer 3M, model 60921
The 3M P100 combination cartridge is a high-performance respiratory protection solution tailored for workers in chemical, petrochemical, construction, and transportation sectors. It features a P100 filter certified under NIOSH 42 CFR 84, capable of capturing 99.97% of solid and liquid particles, including those from oil-based aerosols. Its oil-proof membrane ensures maximum resistance to oil-containing particulates. In parallel, the activated carbon efficiently absorbs organic vapors such as xylene, benzene, industrial solvents, and pesticides. Sold as a pair, this cartridge is a reliable choice for high-concentration chemical environments.
The 3M 60921 cartridge stands out for its dual function: particle filtration and gas absorption. It protects against radioactive particles (uranium, plutonium), heavy metals (lead, cadmium, arsenic), low-level asbestos, and carcinogenic particles such as methylenedianiline (MDA). It is also effective against certain airborne biological particles, including mold spores and influenza viruses. Note: this cartridge does not protect against carbon monoxide (CO) or carbon dioxide (CO₂) and must not be used in oxygen-deficient environments.
To install the 3M P100 combination cartridge, simply attach it to the side connectors of a compatible respirator. Ensure the cartridges are securely locked and sealed to guarantee optimal protection. This cartridge is designed for fast, tool-free installation on 3M respirators from the 6000, 7000 and Ultimate FX FF-400 series.
This type of cartridge is ideal for work in the chemical and petrochemical industries, construction, and transportation. It offers reliable protection against oil-containing aerosol particles, radioactive particles (uranium and plutonium), heavy metal particles (lead, cadmium, arsenic), low-level asbestos, and carcinogenic particles (4,4’-methylenedianiline (MDA)). Do not use this cartridge in environments exceeding 10 times the permissible exposure limit set by CNESST. WARNING: This cartridge does not protect against carbon monoxide (CO) or carbon dioxide (CO₂). If these gases may be present in your work environment, additional protective measures are required.
These cartridges may help reduce inhalation exposure to certain airborne biological particles, such as mold, Bacillus anthracis (anthrax), Mycobacterium tuberculosis (tuberculosis), and pandemic influenza strains (H5N1, H1N1). However, they cannot eliminate the risk of infection, illness, or disease. When protection is needed solely against biological particles, this type of equipment is not recommended. 3M P100 cartridges are designed for workers who may need protection from biological particles in addition to certain gases, vapors, and airborne particulates.
Unlike standard filters, a 3M combination cartridge has two distinct end-of-service life cycles. Here is how to determine when it is time to replace your filters:
As dust, mists, and aerosols saturate the outer pleated layer, the effort required to inhale increases. If you experience increased breathing resistance or difficulty inhaling, the P100 filter is clogged and needs replacement.
If you detect the smell or taste of solvents or chemicals inside your mask, the activated carbon has reached its saturation point (a phenomenon known as "breakthrough"). Replace the pair immediately.
Sylprotec Pro Tip: Activated carbon continues to absorb humidity and airborne contaminants even when not in use. To extend the life of your cartridges, always store them in an airtight bag between shifts.
The effectiveness of your respiratory protection depends on strict adherence to safety standards. The 3M 60921 P100 cartridge must not be used under the following conditions:
Oxygen Deficiency: Never use in atmospheres containing less than 19.5% oxygen.
Non-Targeted Gases: This model is ineffective against carbon monoxide (CO) and carbon dioxide (CO2).
Hazardous Concentrations: Do not use if contaminant levels exceed 10 times the Permissible Exposure Limit (PEL/CNESST) when using a half-mask.
Facial Seal: The presence of a beard or facial hair compromises the seal, reducing your protection to zero.
Use the 3M P100 combination cartridge only in well-ventilated environments that comply with permissible exposure limits. It is ideal for painting, solvent handling, industrial cleaning, and pesticide application. Do not use this cartridge in oxygen-deficient atmospheres or where carbon monoxide is present. For maximum protection, pair it with a properly fitted 3M respirator and follow all safety guidelines relevant to your industry.
Service life depends on the environment and contaminant concentration. Replace the cartridge as soon as odors or breathing discomfort are detected.
No, the 60921 cartridge is designed for organic vapors and particulates. For acid gases, use a specific multi-gas cartridge.
It is compatible with 3M respirators from the 6000, 7000 and FF-400 series. Always verify compatibility before use.
Need additional safety equipment? See the following items: CDN “Cartridge Respirator Required” sign (ECO106), “Notice: Cartridge Respirator Required in This Area” sign (EOAV328), half-face respirator (R6200), full-face respirator (RFF402), or Quick Latch half-face respirator (R6502QL).
Under “Accessories” at the bottom of the page. If you are looking for work equipment, check out the following products: Full-face respirator (R6800), 3M medium air-purifying protective suit (R6800PF) or the large version (R6900PF).
Data sheet
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